diff --git a/src/DIRAC/WorkloadManagementSystem/JobWrapper/JobWrapper.py b/src/DIRAC/WorkloadManagementSystem/JobWrapper/JobWrapper.py
index 30648ba3101..b82f8f134b8 100755
--- a/src/DIRAC/WorkloadManagementSystem/JobWrapper/JobWrapper.py
+++ b/src/DIRAC/WorkloadManagementSystem/JobWrapper/JobWrapper.py
@@ -18,6 +18,7 @@
 import os
 import re
 import shutil
+import signal
 import stat
 import sys
 import tarfile
@@ -1616,6 +1617,9 @@ def run(self):
         """
         log = gLogger.getSubLogger(self.__class__.__name__)
 
+        # Unblock signals left blocked by libraries such as gfal2, which the payload would inherit
+        signal.pthread_sigmask(signal.SIG_SETMASK, set())
+
         start = time.time()
         initialStat = os.times()
         log.verbose("Cmd called", self.cmd)
diff --git a/src/DIRAC/WorkloadManagementSystem/JobWrapper/test/Test_JobWrapper.py b/src/DIRAC/WorkloadManagementSystem/JobWrapper/test/Test_JobWrapper.py
index b30db4a6ccc..e0e180e4df3 100644
--- a/src/DIRAC/WorkloadManagementSystem/JobWrapper/test/Test_JobWrapper.py
+++ b/src/DIRAC/WorkloadManagementSystem/JobWrapper/test/Test_JobWrapper.py
@@ -2,6 +2,8 @@
 
 import os
 import shutil
+import signal
+import sys
 import tempfile
 import time
 from pathlib import Path
@@ -17,7 +19,8 @@
 from DIRAC.Resources.Catalog.test.mock_FC import fc_mock
 from DIRAC.WorkloadManagementSystem.Client import JobMinorStatus, JobStatus
 from DIRAC.WorkloadManagementSystem.JobWrapper.JobExecutionCoordinator import JobExecutionCoordinator
-from DIRAC.WorkloadManagementSystem.JobWrapper.JobWrapper import JobWrapper
+from DIRAC.Core.Utilities.Subprocess import Subprocess
+from DIRAC.WorkloadManagementSystem.JobWrapper.JobWrapper import ExecutionThread, JobWrapper
 
 gLogger.setLevel("DEBUG")
 
@@ -221,6 +224,27 @@ def test_preProcess_dirac_jobexec_with_args(setup_job_wrapper):
 
 
 @pytest.mark.slow
+@pytest.mark.skipif(not sys.platform.startswith("linux"), reason="Reads /proc/self/status")
+def test_executionThread_clears_signal_mask(tmp_path):
+    """The payload must not inherit signals blocked in the JobWrapper (e.g. by gfal2)."""
+    stdout = tmp_path / "std.out"
+    executionResults = {}
+    blocked = {signal.SIGQUIT, signal.SIGTERM}
+    exeThread = ExecutionThread(
+        Subprocess(), "grep SigBlk /proc/self/status", 100, str(stdout), None, os.environ.copy(), executionResults
+    )
+    oldMask = signal.pthread_sigmask(signal.SIG_BLOCK, blocked)
+    try:
+        # The thread inherits the mask of this one when it starts, as it would in the JobWrapper
+        exeThread.start()
+    finally:
+        signal.pthread_sigmask(signal.SIG_SETMASK, oldMask)
+    exeThread.join()
+
+    assert executionResults["Thread"]["OK"], executionResults["Thread"]
+    assert stdout.read_text().split() == ["SigBlk:", "0000000000000000"]
+
+
 def test_processSuccessfulCommand(mocker):
     """Test the process method of the JobWrapper class: most common scenario."""
     jw = JobWrapper()