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ToxPi GitHub 🏡. For current information on ToxPi see: https://toxpi.github.io/



Marvel SW, To K, Grimm FA, Wright FA, Rusyn I, Reif DM. ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models. BMC Bioinformatics. 2018. 19(1):80. https://doi.org/10.1186/s12859-018-2089-2
→Direct download of the Stand-alone Java application (GUI) from toxpi.org: toxpi_v2.3.zip
→Direct download the GUI User Manual (PDF) from toxpi.org/Manual: ToxPi User Manual.pdf

R package for the Toxicological Priority Index (ToxPi) prioritization algorithm.
GitHub for toxpiR package (includes branches under active development with new features): https://github.com/ToxPi/toxpiR
CRAN version of toxpiR package: https://CRAN.R-project.org/package=toxpiR

Fleming J, Marvel SW, Supak S, Motsinger-Reif AA, Reif DM. ToxPi*GIS Toolkit: creating, viewing, and sharing integrative visualizations for geospatial data using ArcGIS. J Expo Sci Environ Epidemiol. 2022 Apr 26:1–8. https://www.nature.com/articles/s41370-022-00433-w
Toolkit for integrating ToxPi models with GIS mapping applications

Filer DL, Patisaul HB, Schug T, Reif D, Thayer, K. Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II. Current Opinion in Pharmacology. 2014. 19:145-152. https://doi.org/10.1016/j.coph.2014.09.021
Methodological advancement in score calculation used in all subsequent ToxPi implementations

Reif DM, Martin MT, Tan SW, Houck KA, Judson RS, Richard AM, Knudsen TB, Dix DJ, Kavlock RF. Endocrine profiling and prioritization of environmental chemicals using ToxCast data. Environmental Health Perspectives. 2010. 118(12):1714-20. https://doi.org/10.1289/ehp.1002180
Original publication

Read published uses of the ToxPi framework

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  1. toxpiR toxpiR Public

    toxpiR R package for the Toxicological Priority Index (ToxPi) algorithm.

    R 11 5

  2. ToxPi-example-files ToxPi-example-files Public

    Repository of example files for ToxPi

    3

  3. ToxPi.github.io ToxPi.github.io Public

    IO web page for the ToxPi organization

Repositories

Showing 6 of 6 repositories
  • toxpiR Public

    toxpiR R package for the Toxicological Priority Index (ToxPi) algorithm.

    ToxPi/toxpiR's past year of commit activity
    R 11 GPL-3.0 5 7 (1 issue needs help) 0 Updated Jun 15, 2026
  • ToxPi.github.io Public

    IO web page for the ToxPi organization

    ToxPi/ToxPi.github.io's past year of commit activity
    0 0 0 0 Updated Oct 24, 2025
  • .github Public
    ToxPi/.github's past year of commit activity
    0 0 0 0 Updated Oct 2, 2025
  • ToxPi-Weight-Optimization Public

    Scripts and results used in Fleming et al, scripts are prior to method incorporation with the toxpiR package and for generating paper results only

    ToxPi/ToxPi-Weight-Optimization's past year of commit activity
    R 0 0 0 0 Updated Feb 14, 2024
  • ToxPi-GIS Public

    Production of shareable, interactive feature layers from the output of the ToxPi GUI

    ToxPi/ToxPi-GIS's past year of commit activity
    Python 1 0 0 0 Updated Jun 9, 2023
  • ToxPi-example-files Public

    Repository of example files for ToxPi

    ToxPi/ToxPi-example-files's past year of commit activity
    0 3 0 0 Updated Feb 2, 2022

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